Structural Congeners of Izenamides Responsible for Cathepsin D Inhibition: Insights from Synthesis-Derived Elucidation

Structural Congeners of Izenamides Responsible for Cathepsin D Inhibition: Insights from Synthesis-Derived Elucidation

This study aimed to elucidate the structural congeners of natural izenamides A, B, and C (<b>1</b>–<b>3</b>) responsible for cathepsin D (CTSD) inhibition. Structurally modified izenamides were synthesized and biologically evaluated, and their biologically important core stru...

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Bibliographic Details
Main Authors: Hyun Su Kim, Hyejin Kong, Taewoo Kim, Changjin Lim, Seungbeom Lee, Seok-Ho Kim, Young-Ger Suh
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Marine Drugs
Subjects:
marine cyanobacteria
izenamides
cathepsin D
linear depsipeptides
statine
Online Access:https://www.mdpi.com/1660-3397/21/5/281

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https://www.mdpi.com/1660-3397/21/5/281

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