Inhibition of Macrophage Migration Inhibitory Factor Activity Attenuates Haemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats

Inhibition of Macrophage Migration Inhibitory Factor Activity Attenuates Haemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats

ObjectiveThe aim of this study was to investigate (a) macrophage migration inhibitory factor (MIF) levels in polytrauma patients and rats after haemorrhagic shock (HS), (b) the potential of the MIF inhibitor ISO-1 to reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-ter...

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Bibliographic Details
Main Authors: Nikita M. Patel, Noriaki Yamada, Filipe R. M. B. Oliveira, Lara Stiehler, Elisabeth Zechendorf, Daniel Hinkelmann, Sandra Kraemer, Christian Stoppe, Massimo Collino, Debora Collotta, Gustavo Ferreira Alves, Hanna Pillmann Ramos, Regina Sordi, Ingo Marzi, Borna Relja, Gernot Marx, Lukas Martin, Christoph Thiemermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
haemorrhagic shock
ischaemia-reperfusion
ISO-1
macrophage migration inhibitory factor
multiple organ dysfunction syndrome
trauma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.886421/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.886421/full

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