Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular carcinoma progression by recruiting RNA-binding protein CELF2 to stabilize SKA1 mRNA

Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular carcinoma progression by recruiting RNA-binding protein CELF2 to stabilize SKA1 mRNA

Abstract Background Long non-coding RNAs (lncRNAs) perform a vital role during the progression of hepatocellular carcinoma (HCC). Here, we aimed to identify a novel lncRNA involved in HCC development and elucidate the underlying molecular mechanism. Methods The RT-qPCR and TCGA dataset analysis were...

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Bibliographic Details
Main Authors: Hang Tuo, Runkun Liu, Yufeng Wang, Wei Yang, Qingguang Liu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:World Journal of Surgical Oncology
Subjects:
Hepatocellular carcinoma
MRVI1-AS1
SKA1
mRNA stability
Hypoxia
Online Access:https://doi.org/10.1186/s12957-023-02993-z

Internet

https://doi.org/10.1186/s12957-023-02993-z

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