Deficient leptin receptor signaling in T cells of human SLE

Deficient leptin receptor signaling in T cells of human SLE

BackgroundSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease mainly mediated by IgG autoantibody. While follicular helper T (Tfh) cells are crucial for supporting IgG autoantibody generation in human SLE, underlying mechanisms for Tfh cell mal-differentiation remain unclear.Method...

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Bibliographic Details
Main Authors: Ting Liu, Ming Zheng, Li Jia, Mingyuan Wang, Longhai Tang, Zhenke Wen, Miaojia Zhang, Fenghong Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
SLE
T cell
leptin
leptin receptor
AMPK
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157731/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1157731/full

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