Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study
Background: Previous studies demonstrated a controversial relationship between sarcopenia (SP) and osteoarthritis (OA) and their genetic causality is unclear. Thus, we conducted a Mendelian randomization (MR) analysis to evaluate the possible causal association between sarcopenia-related traits (app...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1340245/full |
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| author | Xue-Min Jia Xue-Min Jia Ting-Ting Deng Hang Su Hao-Jun Shi Hao Qin Gong-Chang Yu Ying Yin Fan-Jie Liu Fan-Jie Liu Bin Shi Bin Shi |
| author_facet | Xue-Min Jia Xue-Min Jia Ting-Ting Deng Hang Su Hao-Jun Shi Hao Qin Gong-Chang Yu Ying Yin Fan-Jie Liu Fan-Jie Liu Bin Shi Bin Shi |
| author_sort | Xue-Min Jia |
| collection | DOAJ |
| description | Background: Previous studies demonstrated a controversial relationship between sarcopenia (SP) and osteoarthritis (OA) and their genetic causality is unclear. Thus, we conducted a Mendelian randomization (MR) analysis to evaluate the possible causal association between sarcopenia-related traits (appendicular lean mass (ALM), grip strength, usual walking pace) and OA.Method: We used pooled genetic data from the UK Biobank for ALM(n = 450,243), left-hand grip strength (n = 461,026), right-hand grip strength (n = 461,089) and usual walking pace (n = 459,915). Moreover, summary statistics for OA were obtained from the latest study conducted by the Genetics of Osteoarthritis Consortium, including all OA (n = 826,690), hand OA (n = 303,7782), hip OA (n = 353,388) and knee OA (n = 396,054). The primary method for estimating causal effects was the inverse-variance weighted (IVW) method, with the utilizing of false discovery rate adjusted p values (PFDR). Additional MR methods such as MR-Egger regression, MR pleiotropy residual sum and outlier (MR-PRESSO), weighted median were employed as supplementary analyses.Results: We discovered ALM (odds ratio (OR) = 1.103, 95% confidence interval (CI) = 1.052–1.156, PFDR = 2.87E-04), hand grip strength (left, IVW OR = 0.823, 95% CI = 0.712 to 0.952, PFDR = 0.020; right, OR = 0.826, 95% CI = 0.718 to 0.950, PFDR = 0.020), and usual walking pace (OR = 0.339, 95% CI = 0.204 to 0.564, PFDR = 2.38E-04) were causally associated with OA risk. In the reverse MR analysis, we identified a causal effect of OA on ALM (β = −0.258, 95% CI = −0.369 to 0.146, PFDR = 0.6.07E-06), grip strength (left, β = −0.064, 95% CI = −0.104 to 0.024, PFDR = 0.002; right, β = −0.055, 95% CI = −0.095 to 0.014, PFDR = 0.008), and usual walking pace (β = −0.104, 95% CI = −0.147 to 0.061, PFDR = 1.61E-05).Conclusion: This present study suggests an obvious causality of SP on OA, with condition exhibiting site-specific effects, while evidence was also provided for the causal effect of OA on SP. |
| first_indexed | 2024-03-08T16:05:20Z |
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| last_indexed | 2024-03-08T16:05:20Z |
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| spelling | doaj.art-3d06376be55147f4b53c2bf3486b42912024-01-08T05:57:51ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-01-011410.3389/fgene.2023.13402451340245Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization studyXue-Min Jia0Xue-Min Jia1Ting-Ting Deng2Hang Su3Hao-Jun Shi4Hao Qin5Gong-Chang Yu6Ying Yin7Fan-Jie Liu8Fan-Jie Liu9Bin Shi10Bin Shi11Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Rehabilitation, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaSchool of TCM, Macau University of Science and Technology, Macau, ChinaNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaShandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaShandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaShandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaBackground: Previous studies demonstrated a controversial relationship between sarcopenia (SP) and osteoarthritis (OA) and their genetic causality is unclear. Thus, we conducted a Mendelian randomization (MR) analysis to evaluate the possible causal association between sarcopenia-related traits (appendicular lean mass (ALM), grip strength, usual walking pace) and OA.Method: We used pooled genetic data from the UK Biobank for ALM(n = 450,243), left-hand grip strength (n = 461,026), right-hand grip strength (n = 461,089) and usual walking pace (n = 459,915). Moreover, summary statistics for OA were obtained from the latest study conducted by the Genetics of Osteoarthritis Consortium, including all OA (n = 826,690), hand OA (n = 303,7782), hip OA (n = 353,388) and knee OA (n = 396,054). The primary method for estimating causal effects was the inverse-variance weighted (IVW) method, with the utilizing of false discovery rate adjusted p values (PFDR). Additional MR methods such as MR-Egger regression, MR pleiotropy residual sum and outlier (MR-PRESSO), weighted median were employed as supplementary analyses.Results: We discovered ALM (odds ratio (OR) = 1.103, 95% confidence interval (CI) = 1.052–1.156, PFDR = 2.87E-04), hand grip strength (left, IVW OR = 0.823, 95% CI = 0.712 to 0.952, PFDR = 0.020; right, OR = 0.826, 95% CI = 0.718 to 0.950, PFDR = 0.020), and usual walking pace (OR = 0.339, 95% CI = 0.204 to 0.564, PFDR = 2.38E-04) were causally associated with OA risk. In the reverse MR analysis, we identified a causal effect of OA on ALM (β = −0.258, 95% CI = −0.369 to 0.146, PFDR = 0.6.07E-06), grip strength (left, β = −0.064, 95% CI = −0.104 to 0.024, PFDR = 0.002; right, β = −0.055, 95% CI = −0.095 to 0.014, PFDR = 0.008), and usual walking pace (β = −0.104, 95% CI = −0.147 to 0.061, PFDR = 1.61E-05).Conclusion: This present study suggests an obvious causality of SP on OA, with condition exhibiting site-specific effects, while evidence was also provided for the causal effect of OA on SP.https://www.frontiersin.org/articles/10.3389/fgene.2023.1340245/fullsarcopeniaosteoarthritisMendelian randomizationdegenerative musculoskeletal diseasescausal relationship |
| spellingShingle | Xue-Min Jia Xue-Min Jia Ting-Ting Deng Hang Su Hao-Jun Shi Hao Qin Gong-Chang Yu Ying Yin Fan-Jie Liu Fan-Jie Liu Bin Shi Bin Shi Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study Frontiers in Genetics sarcopenia osteoarthritis Mendelian randomization degenerative musculoskeletal diseases causal relationship |
| title | Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study |
| title_full | Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study |
| title_fullStr | Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study |
| title_full_unstemmed | Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study |
| title_short | Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study |
| title_sort | genetic causality and site specific relationship between sarcopenia and osteoarthritis a bidirectional mendelian randomization study |
| topic | sarcopenia osteoarthritis Mendelian randomization degenerative musculoskeletal diseases causal relationship |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1340245/full |
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