TRPM2 enhances ischemic excitotoxicity by associating with PKCγ

TRPM2 enhances ischemic excitotoxicity by associating with PKCγ

Summary: N-methyl-D-aspartate receptor (NMDAR)-mediated glutamate excitotoxicity significantly contributes to ischemic neuronal death and post-recanalization infarction expansion. Despite tremendous efforts, targeting NMDARs has proven unsuccessful in clinical trials for mitigating brain injury. Her...

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Bibliographic Details
Main Authors: Pengyu Zong, Jianlin Feng, Nicholas Legere, Yunfeng Li, Zhichao Yue, Cindy X. Li, Yasuo Mori, Barbara Miller, Bing Hao, Lixia Yue
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000500

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http://www.sciencedirect.com/science/article/pii/S2211124724000500

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