Striatum-projecting prefrontal cortex neurons support working memory maintenance

Abstract Neurons in the medial prefrontal cortex (mPFC) are functionally linked to working memory (WM) but how distinct projection pathways contribute to WM remains unclear. Based on optical recordings, optogenetic perturbations, and pharmacological interventions in male mice, we report here that do...

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Bibliographic Details
Main Authors: Maria Wilhelm, Yaroslav Sych, Aleksejs Fomins, José Luis Alatorre Warren, Christopher Lewis, Laia Serratosa Capdevila, Roman Boehringer, Elizabeth A. Amadei, Benjamin Grewe, Eoin C. O’Connor, Benjamin J. Hall, Fritjof Helmchen
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42777-3