Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial

Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial

Abstract Background Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileum may facilitate removal of free cholesterol from...

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Bibliographic Details
Main Authors: Renger G. Tiessen, Ciara A. Kennedy, Bradley T. Keller, Nancy Levin, Lisette Acevedo, Bronislava Gedulin, Andre A. van Vliet, Alejandro Dorenbaum, Melissa Palmer
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Gastroenterology
Subjects:
Apical sodium-dependent bile acid transporter
Bile acids
Clinical pharmacology
Non-alcoholic steatohepatitis
Non-alcoholic fatty liver disease
Phase 1 clinical trial
Online Access:http://link.springer.com/article/10.1186/s12876-017-0736-0

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http://link.springer.com/article/10.1186/s12876-017-0736-0

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