The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is associated with improved glucose tolerance.

Bibliographic Details
Main Authors: Shota Yoshida, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, Tomohiro Kawano, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi
Format: Article
Language:English
Published: Nature Portfolio 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16347-w

Internet

https://doi.org/10.1038/s41467-020-16347-w

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