Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...

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Bibliographic Details
Main Authors: Huimin Ji, Hongliang Dong, Yuejiao Lan, Yuqian Bi, Xuan Gu, Yongyue Han, Chongyang Yang, Minghan Cheng, Jian Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
metformin
fibroblast activation
S100A4
STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1089812/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1089812/full

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