Accumulation of acetaldehyde in aldh2.1−/− zebrafish causes increased retinal angiogenesis and impaired glucose metabolism

Accumulation of acetaldehyde in aldh2.1−/− zebrafish causes increased retinal angiogenesis and impaired glucose metabolism

Reactive carbonyl species (RCS) are spontaneously formed in the metabolism and modify and impair the function of DNA, proteins and lipids leading to several organ complications. In zebrafish, knockout of the RCS detoxifying enzymes glyoxalase 1 (Glo 1), aldehyde dehydrogenase 3a1 (Aldh3a1) and aldo-...

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Bibliographic Details
Main Authors: David Philipp Wohlfart, Bowen Lou, Chiara Simone Middel, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Rüdiger Hell, Hans-Peter Hammes, Julia Szendrödi, Peter Paul Nawroth, Jens Kroll
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Redox Biology
Subjects:
Aldehyde dehydrogenase (ALDH)
Acetaldehyde (AA)
Reactive carbonyl species (RCS)
Glucose metabolism
Microvascular organ complications
Zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000210

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http://www.sciencedirect.com/science/article/pii/S2213231722000210

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