Multi-Omic Analysis of CIC’s Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity

Multi-Omic Analysis of CIC’s Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity

<i>CIC</i> encodes a transcriptional repressor and MAPK signalling effector that is inactivated by loss-of-function mutations in several cancer types, consistent with a role as a tumour suppressor. Here, we used bioinformatic, genomic, and proteomic approaches to investigate CIC’s intera...

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Bibliographic Details
Main Authors: Yuka Takemon, Véronique G. LeBlanc, Jungeun Song, Susanna Y. Chan, Stephen Dongsoo Lee, Diane L. Trinh, Shiekh Tanveer Ahmad, William R. Brothers, Richard D. Corbett, Alessia Gagliardi, Annie Moradian, J. Gregory Cairncross, Stephen Yip, Samuel A. J. R. Aparicio, Jennifer A. Chan, Christopher S. Hughes, Gregg B. Morin, Sharon M. Gorski, Suganthi Chittaranjan, Marco A. Marra
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
CIC
genetic networks
proteomic interactions
single-cell sequencing
cell cycle
mitosis
Online Access:https://www.mdpi.com/2072-6694/15/10/2805

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https://www.mdpi.com/2072-6694/15/10/2805

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