2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis

2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis

Background 2,5-dimethylcelecoxib (DMC), a derivative of celecoxib, is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). Our previous studies have demonstrated that DMC inhibits the expression of programmed death-ligand 1 on hepatocellular carcinoma (HCC) cells to prevent tumor progres...

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Bibliographic Details
Main Authors: Xiaoxia Zhang, Zhanfei Chen, Nanhong Tang, Banglun Pan, Zengbin Wang, Yuxin Yao, Xiaoxuan Wu, Jiacheng Qiu, Hua Lin, Liumin Yu, Haijian Tu
Format: Article
Language:English
Published: BMJ Publishing Group 2023-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/6/e006817.full

Internet

https://jitc.bmj.com/content/11/6/e006817.full

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