Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals.

Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals.

Currently, MVA virus vectors carrying HIV-1 genes are being developed as HIV-1/AIDS prophylactic/therapeutic vaccines. Nevertheless, little is known about the impact of these vectors on human dendritic cells (DC) and their capacity to present HIV-1 antigens to human HIV-specific T cells. This study...

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Bibliographic Details
Main Authors: Núria Climent, Susana Guerra, Felipe García, Cristina Rovira, Laia Miralles, Carmen Elena Gómez, Núria Piqué, Cristina Gil, José María Gatell, Mariano Esteban, Teresa Gallart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3097254?pdf=render

Internet

http://europepmc.org/articles/PMC3097254?pdf=render

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