HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate

HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate

HIV-1 reverse transcriptase (RT) inhibitors currently used in antiretroviral therapy can be divided into two classes: (i) nucleoside analog RT inhibitors (NRTIs), which compete with natural nucleoside substrates and act as terminators of proviral DNA synthesis, and (ii) non-nucleoside RT inhibitors...

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Bibliographic Details
Main Authors: Giovanni Maga, Marco Radi, Marie-Aline Gerard, Maurizio Botta, Eric Ennifar
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Viruses
Subjects:
HIV
reverse transcriptase
competitive inhibitors
Online Access:http://www.mdpi.com/1999-4915/2/4/880/

Internet

http://www.mdpi.com/1999-4915/2/4/880/

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