Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct thrombin inhibitor that can potentially prevent thrombosis via subcutaneous (SC) and intravenous (IV) administrati...

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Bibliographic Details
Main Authors: Mengfang Wu, Tian Xia, Yaran Li, Tianfa Wang, Shijia Yang, Jinchao Yu, Qiaoyan Liang, Teng Shen, Min Yu, Bing Zhao
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Anticoagulant
r-hirudin
Microneedle patch
3D printing technology
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087622000204

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http://www.sciencedirect.com/science/article/pii/S1818087622000204

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