Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reacti...

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Bibliographic Details
Main Authors: Darina Paprckova, Veronika Niederlova, Alena Moudra, Ales Drobek, Michaela Pribikova, Sarka Janusova, Kilian Schober, Ales Neuwirth, Juraj Michalik, Martina Huranova, Veronika Horkova, Michaela Cesnekova, Michaela Simova, Jan Prochazka, Jana Balounova, Dirk H. Busch, Radislav Sedlacek, Martin Schwarzer, Ondrej Stepanek
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
T cell
self-reactivity
antigen-inexperienced memory-like CD8 T cells
T-cell diversity
interferon response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full

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