Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

Summary: Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ciliogenesis and interferes with the cohesion of duplicated centr...

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Bibliographic Details
Main Authors: Elena Fdez, Jesús Madero-Pérez, Antonio J. Lara Ordóñez, Yahaira Naaldijk, Rachel Fasiczka, Ana Aiastui, Javier Ruiz-Martínez, Adolfo López de Munain, Sally A. Cowley, Richard Wade-Martins, Sabine Hilfiker
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Cellular neuroscience
Cell biology
Functional aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222007477

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http://www.sciencedirect.com/science/article/pii/S2589004222007477

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