Case Report: Successful therapy with all-trans retinoic acid combined with chemotherapy followed by hematopoietic stem cell transplantation for acute promyelocytic leukemia carrying the BCOR-RARA fusion gene

Case Report: Successful therapy with all-trans retinoic acid combined with chemotherapy followed by hematopoietic stem cell transplantation for acute promyelocytic leukemia carrying the BCOR-RARA fusion gene

Acute promyelocytic leukemia (APL) is characterized by the balanced translocation of chromosomes 15 and 17, resulting in the formation of PML-RARA fusion gene. More than 98% of APL have PML-RARA fusion, and less than 2% have other types of RARA gene partners, which named variant APL (vAPL). In the p...

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Bibliographic Details
Main Authors: Li Chen, Hongming Zhu, Yongmei Zhu, Wen Jin, Fangyi Dong, Jianfeng Li, Jiong Hu, Qiusheng Chen, Kankan Wang, Junmin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
acute promyelocytic leukemia
variant
BCOR-RARA
all-trans retinoic acid
allogeneic hematopoietic stem cell transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1013046/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1013046/full

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