In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immunobiology of Allogeneic Transplantation

In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immunobiology of Allogeneic Transplantation

Donor T cell mediated graft versus host effects (GVH) may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA molecules in each donor-recipient pair undergoing stem cell transplantation (SCT). Whole exome sequencing has previously demonstrated a l...

Full description

Bibliographic Details
Main Authors: Max eJameson-Lee, Vishal eKoparde, Phil eGriffith, Allison eScalora, Juliana K Sampson, Haniya eKhalid, Nihar U Sheth, Michael eBatalo, Myrna G Serrano, Catherine H Roberts, Michael L Hess, Gregory A Buck, Michael C Neale, Masoud H Manjili, Amir Ahmed Toor
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Immunology
Subjects:
Peptides
exome sequencing
alloreactivity
allogeneic stem cell transplantation
HLA-peptide binding affinity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00529/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00529/full

Similar Items