Longitudinal microbial and molecular dynamics in the cystic fibrosis lung after Elexacaftor–Tezacaftor–Ivacaftor therapy

Longitudinal microbial and molecular dynamics in the cystic fibrosis lung after Elexacaftor–Tezacaftor–Ivacaftor therapy

Abstract Background Cystic fibrosis (CF) is a genetic disorder causing poor mucociliary clearance in the airways and subsequent respiratory infection. The recently approved triple therapy Elexacaftor–Tezacaftor–Ivacaftor (ETI) has significantly improved lung function and decreased airway infection i...

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Bibliographic Details
Main Authors: Christian Martin, Douglas V. Guzior, Cely T. Gonzalez, Maxwell Okros, Jenna Mielke, Lienwil Padillo, Gabriel Querido, Marissa Gil, Ryan Thomas, Marc McClelland, Doug Conrad, Stefanie Widder, Robert A. Quinn
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Respiratory Research
Subjects:
Cystic fibrosis
Microbiome
Metabolome
Neutral models
Elexacaftor–Tezacaftor–Ivacaftor
Pseudomonas aeruginosa
Online Access:https://doi.org/10.1186/s12931-023-02630-z

Internet

https://doi.org/10.1186/s12931-023-02630-z

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