Insights Into the Bifunctional Aphidicolan-16-ß-ol Synthase Through Rapid Biomolecular Modeling Approaches

Insights Into the Bifunctional Aphidicolan-16-ß-ol Synthase Through Rapid Biomolecular Modeling Approaches

Diterpene synthases catalyze complex, multi-step C-C coupling reactions thereby converting the universal, aliphatic precursor geranylgeranyl diphosphate into diverse olefinic macrocylces that form the basis for the structural diversity of the diterpene natural product family. Since catalytically rel...

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Bibliographic Details
Main Authors: Max Hirte, Nicolas Meese, Michael Mertz, Monika Fuchs, Thomas B. Brück
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Chemistry
Subjects:
homology modeling
aphidicolin
diterpene
diterpene synthase
homology model refinement
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00101/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00101/full

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