Functional Deimmunization of Interferon Beta-1b by Identifying and Silencing Human T Cells Epitopes

Functional Deimmunization of Interferon Beta-1b by Identifying and Silencing Human T Cells Epitopes

Interferonbeta-1b (IFNβ-1b) developed as therapeutic protein for the treatment of multiple sclerosis (MS). Studies have been shown that Long-term usage of this protein can lead to the development of anti-drug antibodies (ADAs) and this phenomenon cause total loss or reduced efficacy of IFNβ-1b. The...

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Bibliographic Details
Main Authors: Amin Moradi Hasan-Abad, Elham Adabi, Esmaeil Sadroddiny, Mohammad Reza Khorramizadeh, Mohammad Ali Mazlomi, Saeed Mehravar, Gholam Ali Kardar
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2019-08-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
Anti-drug antibodies
Computational protein design
Deimmunization
Interferon-beta-1b
T-cell epitope
Therapeutic protein
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2192

Internet

https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2192

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