Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling

Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling

Endogenous plasma levels of the immunomodulatory carbohydrate-binding protein galectin-9 (Gal-9) are elevated during HIV infection and remain elevated after antiretroviral therapy (ART) suppression. We recently reported that Gal-9 regulates HIV transcription and potently reactivates latent HIV. Howe...

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Bibliographic Details
Main Authors: Florent Colomb, Leila B. Giron, Thomas A. Premeaux, Brooks I. Mitchell, Toshiro Niki, Emmanouil Papasavvas, Luis J. Montaner, Lishomwa C. Ndhlovu, Mohamed Abdel-Mohsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
HIV
lectins
galectin-9
T cell receptor
TCR signaling
rapamycin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00267/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00267/full

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