Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

Abstract Tau pathology in Alzheimer’s disease (AD) spreads in a predictable pattern that corresponds with disease symptoms and severity. At post-mortem there are cortical regions that range from mildly to severely affected by tau pathology and neuronal loss. A comparison of the molecular signatures...

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Bibliographic Details
Main Authors: Boris Guennewig, Julia Lim, Lee Marshall, Andrew N. McCorkindale, Patrick J. Paasila, Ellis Patrick, Jillian J. Kril, Glenda M. Halliday, Antony A. Cooper, Greg T. Sutherland
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83872-z

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https://doi.org/10.1038/s41598-021-83872-z

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