Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles

Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles

Abstract Background Due to interindividual variation in the cellular composition of the human cortex, it is essential that covariates that capture these differences are included in epigenome-wide association studies using bulk tissue. As experimentally derived cell counts are often unavailable, comp...

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Bibliographic Details
Main Authors: Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk, Jonathan Mill
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Biology
Subjects:
DNA methylation
Brain
Neurons
Glia
Cellular heterogeneity
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12915-024-01827-y

Internet

https://doi.org/10.1186/s12915-024-01827-y

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