LFSC: A linear fast semi-supervised clustering algorithm that integrates reference-bulk and single-cell transcriptomes

The identification of cell types in complex tissues is an important step in research into cellular heterogeneity in disease. We present a linear fast semi-supervised clustering (LFSC) algorithm that utilizes reference samples generated from bulk RNA sequencing data to identify cell types from single...

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Bibliographic Details
Main Authors: Qiaoming Liu, Yingjian Liang, Dong Wang, Jie Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1068075/full