In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series

Objectives: Three new chemical series (bicyclic nitroimidazoles, aminopyrazoles and oxaboroles) were selected by Drugs for Neglected Diseases initiative as potential new drug leads for leishmaniasis. Pharmacodynamics studies included both in vitro and in vivo efficacy, cross-resistance profiling aga...

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Bibliographic Details
Main Authors: M. Van den Kerkhof, D. Mabille, E. Chatelain, C.E. Mowbray, S. Braillard, S. Hendrickx, L. Maes, G. Caljon
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320717301598