A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA release

A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA release

Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2aL174Q rat) c...

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Bibliographic Details
Main Authors: Kentaro Tokudome, Takahiro Okumura, Ryo Terada, Saki Shimizu, Naofumi Kunisawa, Tomoji Mashimo, Tadao Serikawa, Masashi Sasa, Yukihiro Ohno
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Pharmacology
Subjects:
Amygdala
GABA release
glutamate release
Pentylentetrazole
seizure susceptibility
Synaptic vesicle glycoprotein 2A (SV2A)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00210/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00210/full

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