Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension

Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension

The hexosamine biosynthetic pathway (HBP) converts glucose to uridine-diphosphate-<i>N</i>-acetylglucosamine, which, when added to serines or threonines, modulates protein function through protein O-GlcNAcylation. Glutamine-fructose-6-phosphate amidotransferase (GFAT) regulates HBP flux,...

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Bibliographic Details
Main Authors: Sasha Z. Prisco, Lauren Rose, Francois Potus, Lian Tian, Danchen Wu, Lynn Hartweck, Ruaa Al-Qazazi, Monica Neuber-Hess, Megan Eklund, Steven Hsu, Thenappan Thenappan, Stephen L. Archer, Kurt W. Prins
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
right ventricle
pulmonary hypertension
metabolism
post-translational modification
mitochondria
Online Access:https://www.mdpi.com/1422-0067/21/19/7278

Internet

https://www.mdpi.com/1422-0067/21/19/7278

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