Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA.

Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA.

Circulating tumor DNA (ctDNA) is released from tumor cells into blood in advanced cancer patients. Although gene mutations in individual tumors can be diverse and heterogenous, ctDNA has the potential to provide comprehensive biomarker information. Here, we performed multi-region sampling (three sit...

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Bibliographic Details
Main Authors: Noriyuki Sasaki, Takeshi Iwaya, Takehiro Chiba, Masashi Fujita, Zhenlin Ju, Fumitaka Endo, Mizunori Yaegashi, Tsuyoshi Hachiya, Ryo Sugimoto, Tamotsu Sugai, Doris R Siwak, Lance A Liotta, Yiling Lu, Gordon B Mills, Hidewaki Nakagawa, Satoshi S Nishizuka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239966

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https://doi.org/10.1371/journal.pone.0239966

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