Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia

Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia

Compelling evidence has shown that interferon (IFN)-γ has dual effects in multiple sclerosis and in its animal model of experimental autoimmune encephalomyelitis (EAE), with results supporting both a pathogenic and beneficial function. However, the mechanisms whereby IFN-γ may promote neuroprotectio...

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Bibliographic Details
Main Authors: Juan E. Tichauer, Gabriel Arellano, Eric Acuña, Luis F. González, Nirmal R. Kannaiyan, Paola Murgas, Concepción Panadero-Medianero, Jorge Ibañez-Vega, Paula I. Burgos, Eileah Loda, Stephen D. Miller, Moritz J. Rossner, Peter J. Gebicke-Haerter, Rodrigo Naves
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
experimental autoimmune encephalomyelitis
interferon-gamma
microglia
myeloid cells
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1191838/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1191838/full

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