Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs

Antisense oligonucleotide (ASO)-based drug development is gaining significant momentum following the recent FDA approval of Eteplirsen (an ASO based on phosphorodiamidate morpholino) and Spinraza (2′-O-methoxyethyl-phosphorothioate) in late 2016. Their attractiveness is mainly due to the backbone mo...

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Bibliographic Details
Main Authors: Julien Tailhades, Hotake Takizawa, Michael J. Gait, Don A. Wellings, John D. Wade, Yoshitsugu Aoki, Fazel Shabanpoor
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Chemistry
Subjects:
duchenne muscular dystrophy
peptide nucleic acid
cell penetrating peptide
Hmb incorporation
PNA conjugation
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2017.00081/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2017.00081/full

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