Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson’s Disease: Development and Progression of Object Recognition Memory Deficits in Male Pink1–/– Rats

Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson’s Disease: Development and Progression of Object Recognition Memory Deficits in Male Pink1–/– Rats

Cognitive impairments appear at or before motor signs in about one third of patients with Parkinson’s disease (PD) and have a cumulative prevalence of roughly 80% overall. These deficits exact an unrelenting toll on patients’ quality and activities of daily life due in part to a lack of available tr...

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Bibliographic Details
Main Authors: Claudia C. Pinizzotto, Katherine M. Dreyer, Oluwagbohunmi A. Aje, Ryan M. Caffrey, Keertana Madhira, Mary F. Kritzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
cognition
PTEN-induced putative kinase1
spatial memory
perirhinal cortex
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.951268/full

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https://www.frontiersin.org/articles/10.3389/fnbeh.2022.951268/full

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