The Vascular-Ablative Agent VEGF121/rGel Inhibits Pulmonary Metastases of MDA-MB-231 Breast Tumors

The Vascular-Ablative Agent VEGF121/rGel Inhibits Pulmonary Metastases of MDA-MB-231 Breast Tumors

VEGF121/rGel, a fusion protein composed of the growth factor VEGF121 and the recombinant toxin gelonin (rGel), targets the tumor neovasculature and exerts impressive cytotoxic effects by inhibiting protein synthesis. We evaluated the effect of VEGF121/rGel on the growth of metastatic MDA-MB-231 tumo...

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Bibliographic Details
Main Authors: Sophia Ran, Khalid A. Mohamedali, Troy A. Luster, Philip E. Thorpe, Michael G. Rosenblum
Format: Article
Language:English
Published: Elsevier 2005-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
VEGF
gelonin
fusion toxin
vascular targeting
metastatic breast tumors
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800557

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http://www.sciencedirect.com/science/article/pii/S1476558605800557

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