The Effect of Belantamab Mafodotin on Primary Myeloma–Stroma Co-Cultures: Asymmetrical Mitochondrial Transfer between Myeloma Cells and Autologous Bone Marrow Stromal Cells

The Effect of Belantamab Mafodotin on Primary Myeloma–Stroma Co-Cultures: Asymmetrical Mitochondrial Transfer between Myeloma Cells and Autologous Bone Marrow Stromal Cells

Belantamab mafodotin (belamaf) is an afucosylated monoclonal antibody conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF) that targets B cell maturation antigen (BCMA) on the surface of malignant plasma cells. Belamaf can eliminate myeloma cells (MMs) through several mechanisms. O...

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Bibliographic Details
Main Authors: Zsolt Matula, Ferenc Uher, István Vályi-Nagy, Gábor Mikala
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
multiple myeloma
belantamab mafodotin
mitochondrial transfer
cancer drug resistance
bone marrow mesenchymal stromal cell
Online Access:https://www.mdpi.com/1422-0067/24/6/5303

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https://www.mdpi.com/1422-0067/24/6/5303

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