SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

Abstract SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during human mesenchymal stem cell (hMSC) a...

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Bibliographic Details
Main Authors: Shijia Bi, Zunpeng Liu, Zeming Wu, Zehua Wang, Xiaoqian Liu, Si Wang, Jie Ren, Yan Yao, Weiqi Zhang, Moshi Song, Guang-Hui Liu, Jing Qu
Format: Article
Language:English
Published: Oxford University Press 2020-06-01
Series:Protein & Cell
Subjects:
SIRT7
stem cell
aging
LINE1
cGAS
STING
Online Access:https://doi.org/10.1007/s13238-020-00728-4

Internet

https://doi.org/10.1007/s13238-020-00728-4

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