5′-Methylthioadenosine strongly suppresses RANKL-induced osteoclast differentiation and function via inhibition of RANK-NFATc1 signalling pathways

5′-Methylthioadenosine strongly suppresses RANKL-induced osteoclast differentiation and function via inhibition of RANK-NFATc1 signalling pathways

Excessive osteoclast-mediated bone resorption is a critical cause of osteoporosis affecting many aging people worldwide. 5′-Methylthioadenosine (MTA) is a natural sulfur-containing nucleoside normally produced in prokaryotes, plants, yeast, and higher eukaryotes via polyamine metabolism. MTA affects...

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Bibliographic Details
Main Authors: Purithat Rattajak, Aratee Aroonkesorn, Carl Smythe, Rapepun Wititsuwannakul, Thanawat Pitakpornpreecha
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
5′-methylthioadenosine (MTA)
Osteoclastogenesis
Osteoporosis
RAW 264.7 cells
Estrogen
Bone mass
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023095737

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023095737

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