Triiodothyronine (T3) upregulates the expression of proto-oncogene TGFA independent of MAPK/ERK pathway activation in the human breast adenocarcinoma cell line, MCF7

Triiodothyronine (T3) upregulates the expression of proto-oncogene TGFA independent of MAPK/ERK pathway activation in the human breast adenocarcinoma cell line, MCF7

ABSTRACT Objective: To verify the physiological action of triiodothyronine T3 on the expression of transforming growth factor α (TGFA) mRNA in MCF7 cells by inhibition of RNA Polymerase II and the MAPK/ERK pathway Materials and methods: The cell line was treated with T3 at a physiological dose (10...

Full description

Bibliographic Details
Main Authors: Tabata M. Silva, Fernanda C. F. Moretto, Maria T. De Sibio, Bianca M. Gonçalves, Miriane Oliveira, Regiane M. C. Olimpio, Diego A. M. Oliveira, Sarah M. B. Costa, Igor C. Deprá, Vickeline Namba, Maria T. Nunes, Célia R. Nogueira
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2019-03-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Thyroid hormone
nongenomic actions
gene expression
breast cancer
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000200142&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000200142&lng=en&tlng=en

Similar Items