Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

Abstract Summary Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. In this study, we observed increased passive tension (PT) of skinned myofibers fro...

Full description

Bibliographic Details
Main Authors: Andreas Unger, Lisa Beckendorf, Pierre Böhme, Rudolf Kley, Marion von Frieling-Salewsky, Hanns Lochmüller, Rolf Schröder, Dieter O. Fürst, Matthias Vorgerd, Wolfgang A. Linke
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Acta Neuropathologica Communications
Subjects:
Myofibrillar myopathy
Muscular dystrophy
Muscle stiffness
Molecular chaperones
Immunoelectron microscopy
Online Access:http://link.springer.com/article/10.1186/s40478-017-0474-0

Internet

http://link.springer.com/article/10.1186/s40478-017-0474-0

Similar Items