Pressure Adaptations in Deep-Sea <i>Moritella</i> Dihydrofolate Reductases: Compressibility versus Stability

Pressure Adaptations in Deep-Sea <i>Moritella</i> Dihydrofolate Reductases: Compressibility versus Stability

Proteins from “pressure-loving” piezophiles appear to adapt by greater compressibility via larger total cavity volume. However, larger cavities in proteins have been associated with lower unfolding pressures. Here, dihydrofolate reductase (DHFR) from a moderate piezophile <i>Moritella profunda...

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Bibliographic Details
Main Authors: Ryan W. Penhallurick, Toshiko Ichiye
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biology
Subjects:
deep-sea adaptations
compressibility
cavities
pressure
potential energy landscape
Online Access:https://www.mdpi.com/2079-7737/10/11/1211

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