IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment

IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the development and disease by regulating mRNA stability and translation of critical regulators of cell division and metabolism. Genetic and chemical...

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Bibliographic Details
Main Authors: Irina A. Elcheva, Chethana P. Gowda, Daniel Bogush, Svetlana Gornostaeva, Anna Fakhardo, Neil Sheth, Kathleen M. Kokolus, Arati Sharma, Sinisa Dovat, Yasin Uzun, Todd D. Schell, Vladimir S. Spiegelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
IGF2BP/IMP
RNA-binding protein (RBP)
interferon-stimulated genes (ISGs)
melanoma
leukemia
anti-PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1224516/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1224516/full

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