Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection

While mitochondrial bioenergetic deregulation has long been implicated in cellular senescence, its mechanistic involvement remains unclear. By leveraging diverse mitochondria-related gene expression profiles derived from two different cellular senescence models of human diploid fibroblasts, we found...

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Bibliographic Details
Main Authors: Seongki Min, So Mee Kwon, Jiwon Hong, Young-Kyoung Lee, Tae Jun Park, Su Bin Lim, Gyesoon Yoon
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
mitoribosome
replicative senescence
shelterin
telomere maintenance
Online Access:https://www.mdpi.com/2073-4409/11/13/2079

Internet

https://www.mdpi.com/2073-4409/11/13/2079

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