Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding

Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding

The pharmacokinetics in patients with cystic fibrosis (CF) has long been thought to differ considerably from that in healthy volunteers. For highly protein bound β-lactams, profound pharmacokinetic differences were observed between comparatively morbid patients with CF and healthy volunteers. These...

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Bibliographic Details
Main Authors: Nirav R. Shah, Jürgen B. Bulitta, Martina Kinzig, Cornelia B. Landersdorfer, Yuanyuan Jiao, Dhruvitkumar S. Sutaria, Xun Tao, Rainer Höhl, Ulrike Holzgrabe, Frieder Kees, Ulrich Stephan, Fritz Sörgel
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
cystic fibrosis patients
healthy volunteers
cefotiam
beta-lactam antibiotics
population pharmacokinetics
protein binding
allometric scaling
body size
body composition
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Online Access:https://www.mdpi.com/1999-4923/11/6/286

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https://www.mdpi.com/1999-4923/11/6/286

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