ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis

ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis

Estrogen-related receptor alpha (ERRα) plays an important role in endometrial cancer (EC) progression. However, the biological roles of ERRα in EC invasion and metastasis are not clear. This study aimed to investigate the role of ERRα and 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) in regulat...

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Bibliographic Details
Main Authors: Shuting Tang, Jincheng Ma, Pingping Su, Huifang Lei, Yao Tong, Liangzhi Cai, Shuxia Xu, Xiaodan Mao, Pengming Sun
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
endometrial cancer
ERRα
HMGCS1
intracellular cholesterol metabolism
invadopodia
epithelial–mesenchymal transition pathway
Online Access:https://www.mdpi.com/1422-0067/24/4/4010

Internet

https://www.mdpi.com/1422-0067/24/4/4010

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