| Summary: | The lipophilicity parameters (log<i>P<sub>calcd</sub></i>, <i>R<sub>M</sub></i><sub>0</sub> and log<i>P<sub>TLC</sub></i>) of 10 new active anticancer dipirydothiazines with a 1,2,3-triazole ring were determined theoretically using computational methods and experimentally by reversed-phase TLC. Experimental lipophilicity was assessed using mobile phases (a mixture of TRIS buffer and acetone) using a linear correlation between the <i>R<sub>M</sub></i> retention parameter and the volume of acetone. The <i>R<sub>M</sub></i><sub>0</sub> parameter was correlated with the specific hydrophobic surface b, revealing two congenerative subgroups: 1,2,3-triazole-1,6-diazaphenothiazines and 1,2,3-triazole-1,8-diazaphenothiazines hybrids. The <i>R<sub>M</sub></i><sub>0</sub> parameter was converted into the log<i>P<sub>TLC</sub></i> lipophilicity parameter using a calibration curve. The investigated compounds appeared to be moderately lipophilic. Lipophilicity has been compared with molecular descriptors and ADME properties. The new derivatives followed Lipinski’s, Ghose’s and Veber’s rules.
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