Cyclodextrin derivatives decrease Transient Receptor Potential vanilloid 1 and Ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion

Cyclodextrin derivatives decrease Transient Receptor Potential vanilloid 1 and Ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion

Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are nonselective cation channels expressed in primary sensory neurons and several other non-neuronal structures such as immune cells, keratinocytes, and vascular smooth muscle cells. They play important roles in nociception, pain...

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Bibliographic Details
Main Authors: Andrea Kinga Nehr-Majoros, János Erostyák, Éva Fenyvesi, Edina Szabó-Meleg, Levente Szőcs, György Sétáló, Zsuzsanna Helyes, Éva Szőke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lipid raft
cyclodextrin
cholesterol
TRPA1
TRPV1
pain
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1334130/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1334130/full

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