Murine Beta-Amyloid (1–42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors

Murine Beta-Amyloid (1–42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors

Transgenic mouse models of Alzheimer’s disease (AD) overexpress mutations of the human amyloid protein precursor (<i>APP</i>) and presenilin-1 (<i>PSEN1</i>) genes, which are known causes of amyloid pathology in familial AD. However, animal models for studying AD in the conte...

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Bibliographic Details
Main Authors: Qian Yue, Xinhua Zhou, Zaijun Zhang, Maggie Pui Man Hoi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain barrier
murine amyloid-beta
endothelial cells
astrocytes
tight junctions
VEGFR2 signaling pathway
Online Access:https://www.mdpi.com/1422-0067/23/3/1878

Internet

https://www.mdpi.com/1422-0067/23/3/1878

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