Murine Beta-Amyloid (1–42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors
Transgenic mouse models of Alzheimer’s disease (AD) overexpress mutations of the human amyloid protein precursor (<i>APP</i>) and presenilin-1 (<i>PSEN1</i>) genes, which are known causes of amyloid pathology in familial AD. However, animal models for studying AD in the conte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/3/1878 |