Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment

Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment

Abstract Background In solid organ transplant (SOT) recipients, transplant rejection during immune checkpoint inhibitor (ICI) treatment for cancer is a clinical problem. Donor-derived cell-free DNA (dd-cfDNA) can be detected in blood and is a sensitive biomarker for diagnosis of acute rejection in S...

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Bibliographic Details
Main Authors: Daan P. Hurkmans, Jeroen G. H. P. Verhoeven, Kitty de Leur, Karin Boer, Arjen Joosse, Carla C. Baan, Jan H. von der Thüsen, Ron H. N. van Schaik, Ron H. J. Mathijssen, Astrid A. M. van der Veldt, Dennis A. Hesselink
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Allograft rejection
Anti-PD-1
Dd-cfDNA
Melanoma
Donor-derived cell-free DNA
Immune checkpoint inhibition
Online Access:http://link.springer.com/article/10.1186/s40425-019-0653-6

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http://link.springer.com/article/10.1186/s40425-019-0653-6

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