Characterizing Benzo[a]pyrene Adducts in Transfer RNAs Using Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC-MS/MS)

Characterizing Benzo[a]pyrene Adducts in Transfer RNAs Using Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC-MS/MS)

The activated forms of the environmental pollutant benzo[a]pyrene (B[a]P), such as benzo[a]pyrene diol epoxide (BPDE), are known to cause damage to genomic DNA and proteins. However, the impact of BPDE on ribonucleic acid (RNA) remains unclear. To understand the full spectrum of potential BPDE-RNA a...

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Bibliographic Details
Main Authors: Cassandra Herbert, Corinna L. Ohrnberger, Ella Quinlisk, Balasubrahmanyam Addepalli, Patrick A. Limbach
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomedicines
Subjects:
post-transcriptional modifications
adductome
B[a]P
BPDE
RNA adducts
modified nucleosides
Online Access:https://www.mdpi.com/2227-9059/11/12/3270

Internet

https://www.mdpi.com/2227-9059/11/12/3270

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